Tooth loss associated with dementia
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- Published: Monday, 13 March 2017 10:24
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A recent study has found that tooth loss was associated with an increased risk of dementia. The study involved more than 1,500 elderly people in Japan who had their health monitored between 2007 and 2012. The study found participants with fewer teeth had a greater chance of developing dementia within the five years of the study.
The study was carried out by researchers from Kyushu University in Japan, and was funded by the Ministry for Education, Culture, Sports, Science and Technology of Japan, the Ministry of Health, Labour and Welfare of Japan, and the Japan Agency for Medical Research and Development. It was published in the peer-reviewed Journal of the American Geriatrics Society and is free to read online.
Researchers followed 1,566 adults aged 60 or above in one region of Japan. They had their teeth checked by a dentist and were asked about many aspects of their lives. They were followed up closely for five years (2007-12) to check for signs of dementia. After adjusting for confounding factors, the researchers looked at whether people with less than 20 remaining teeth were more likely to have developed dementia of any type, compared with those with at least 20 teeth.
Diagnoses of dementia were made by specialist stroke physicians and psychiatrists. They aimed to differentiate between Alzheimer's disease and vascular dementia, which is caused by multiple small strokes that damage the brain. Researchers adjusted figures to take account of a wide range of potential confounding factors, including people's age, sex, job, history of high blood pressure, stroke or diabetes, education levels, smoking and alcohol intake, tooth brushing frequency, use of dentures, and regular visits to the dentist. They looked at the risk of getting any type of dementia, then at the risks of Alzheimer's disease and vascular dementia separately.
During the study, 180 people (11.5%) developed some type of dementia. Compared with people who had 20 teeth or more:
- those with 10-19 teeth had a 62% higher risk of dementia (hazard ratio [HR] 1.62, 95% confidence interval [CI] 1.06 to 2.46)
- those with 1-9 teeth had an 81% higher risk of dementia (HR 1.81, 95% CI 1.11 to 2.94)
- those with no teeth had a 63% higher risk of dementia, although this figure could have been down to chance, probably because of the small number of people in the study with no teeth (HR 1.63, 95% CI 0.95 to 2.80) – these results could also be affected by people with no teeth wearing a full set of dentures
The researchers found no link between number of teeth and vascular dementia. Although they found a link between numbers of teeth and Alzheimer's disease, this number didn't stand up after adjusting for confounding factors.
The researchers said: "These findings highlighted the clinical value of maintaining healthy dentition [teeth] throughout life to reduce the risk of dementia in the general population."
They suggest several ways in which tooth loss may be linked to dementia risk. They say the act of chewing might stimulate blood flow to the brain, or people with a full set of teeth may have a healthier diet, and inflammation from long-term tooth decay or gum disease might increase the likelihood of Alzheimer's disease. They also admit that poor oral health could be a general sign of overall poor health.
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